Haematology and immunology

Immune-mediated thrombocytopenia (ITP)

Emergency

Also known as: ITP; Immune-mediated thrombocytopaenia

EMERGENCY. This condition can be life-threatening. Take your dog to a veterinarian immediately. See the Emergency & first aid chapter for triage.

Overview

The immune system destroys the platelets that make blood clot, so the dog bleeds spontaneously into the skin and mucous membranes. The tell-tale sign is petechiae — pinpoint red dots that, unlike a rash, do not blanch when pressed. As with IMHA, tick-borne disease is an important trigger in tick-endemic regions and is investigated at the same time. It can occur alongside IMHA. Diagnosis is by platelet count; management is immunosuppressive (class chosen by the vet) plus strict rest, because the risk is bleeding into the brain or gut. Any spontaneous bruising or bleeding in a dog is an immediate veterinary matter.

What you would notice

  • Pinpoint red spots on the gums, belly, or inner ear flap
  • Bruising with no memory of an injury
  • Nosebleeds, or blood in urine or stool
  • Black, tarry stool (digested blood)
  • Lethargy and pale gums if blood loss has been significant
Non-prescriptive. This entry deliberately does NOT name specific drugs, doses, routes, or durations. Treatment decisions rest with a licensed veterinarian who has examined your dog and considered its history.
Draft — vet review pending. This entry has not yet been signed off by a registered veterinarian.

Sources

  • Merck Veterinary Manual (merckvetmanual.com)
  • MSD Veterinary Manual (msdvetmanual.com)
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